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KMID : 0191119920070010001
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Journal of Korean Medical Science
1992 Volume.7 No. 1 p.1 ~ p.5
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Lung adenoma development and NK activity in mice treated with multiple carcinogens
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Lee YS
Seo JS/Chung HT/Cho KJ/Jan JJ
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Abstract
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A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination
had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
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KEYWORD
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